THERAPY DOSSIER · th-c007b0371918

Ot-WHP, a wound healing-promoting peptide from Odorrana tormota

Biologic · Amphibian skin-derived wound-healing peptide; not in ChEMBL (peptide, preclinical). No ClinicalTrials.gov record (searched, not assumed); the wound-healing-peptide query returned only unrelated oncology studies and Granexin gel (an alpha-connexin carboxyl-terminal peptide), excluded as a different molecule.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Amphibian skin-derived wound-healing peptide; not in ChEMBL (peptide, preclinical). No ClinicalTrials.gov record (searched, not assumed); the wound-healing-peptide query returned only unrelated oncology studies and Granexin gel (an alpha-connexin carboxyl-terminal peptide), excluded as a different molecule.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31681309 ↗2019Reported benefit

A Frog-Derived Immunomodulatory Peptide Promotes Cutaneous Wound Healing by Regulating Cellular Response.

MouseWoundBALB/cFemalen = n = 6 mice per group for the wound model and histologyTopical application to the wound20 microlitres per wound at 200 micrograms/mLTreatment began on the day of wounding (day 0)

Model: Full-thickness dorsal skin wound created with an 8 mm biopsy punch under sodium pentobarbital anaesthesia

Topical Ot-WHP significantly accelerated full-thickness wound repair relative to PBS, with healing rates of 67.7, 81.5, 84.8 and 88.5 per cent at days 2, 4, 6 and 8, comparable to the AH90 and EGF positive controls, while scrambled peptide had no effect. Histology showed improved epidermal regenera…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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Ot-WHP, a wound healing-promoting peptide from Odorrana tormota