Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury.
RatSpinal cord injuryComplete transectionWistarFemalen = n = 24 rats underwent telemetry implantation and T4 transec…Intraperitoneal100 mg/kg per injection, 400 mg/kg/dayFirst injection immediately after injury
Model: Complete T4 spinal cord transection after T3 laminectomy, with telemetric blood pressure transmitters implanted in the descending abdominal aorta one week before injury
Continuous high-dose gabapentin significantly lowered the absolute mean arterial pressure reached during colorectal distension induced autonomic dysreflexia at 21 and 28 days and reduced pressor responses to handling, although the change in MAP relative to baseline showed no treatment effect. Parad…
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