Acute Effects of Gabapentin on Polysomnography Parameters and Endocrine Axes During Sleep in Older Men
Sleep
Enrolment: 8 · Results not recorded
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Drug · Voltage-gated calcium channel modulator (MODULATOR; direct interaction; alpha2delta-1 binding site)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sleep
Enrolment: 8 · Results not recorded
Pain, Postoperative
Enrolment: 17 · Results not recorded
Alcohol Dependence
Enrolment: 25 · Results not recorded
Hot Flashes · Menopause
Enrolment: 200 · Results not recorded
Head and Neck Squamous Cell Carcinoma
Enrolment: 228 · Results not recorded
Nausea and Vomiting · Unspecified Adult Solid Tumor, Protocol Specific
Enrolment: 430 · Results not recorded
Insomnia Due to Medical Condition · Chronic Pain
Enrolment: 9 · Results not recorded
Epilepsy and Neuropathic Pain
Enrolment: 51 · Results not recorded
Acute Pain
Enrolment: 100 · Results not recorded
Pharmacokinetics · Healthy Volunteer
Enrolment: 16 · Results not recorded
Postural Orthostatic Tachycardia Syndrome
Enrolment: 10 · Results not recorded
Anterior Cruciate Ligament (ACL) Reconstruction
Enrolment: 57 · Results not recorded
Herpes Zoster
Enrolment: 120 · Results not recorded
Cerebral Tumor
Enrolment: 122 · Results not recorded
Pain
Enrolment: 107 · Results not recorded
Epilepsies, Partial
Enrolment: 82 · Results not recorded
Healthy
Enrolment: 30 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Complete transection spinal cord injury at T4
Acute gabapentin attenuated both muscular spasticity and autonomic dysreflexia evoked by noxious stimuli after SCI.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Complete T4 spinal cord transection after T3 laminectomy, with telemetric blood pressure transmitters implanted in the descending abdominal aorta one week before injury
Continuous high-dose gabapentin significantly lowered the absolute mean arterial pressure reached during colorectal distension induced autonomic dysreflexia at 21 and 28 days and reduced pressor responses to handling, although the change in MAP relative to baseline showed no treatment effect. Parad…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: L5-L6 spinal nerve ligation
Gabapentin dose-dependently decreased locus coeruleus GABA concentrations in normal rats, and only the 50 mg/kg dose did so in nerve-ligated rats, with a greater absolute decrease in ligated rats. In the spinal dorsal horn gabapentin had no effect in normal rats and slightly increased GABA in ligat…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.