Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyFemalen = 48 adult female Sprague-Dawley rats randomly divided into t…Intraperitoneal injection10 mg/kg/dayImmediately after surgery
Model: Spinal cord injury by T8 laminectomy and vascular clip compression (15 g force) for 1 minute
Astragaloside IV treated rats recovered better than untreated injured rats on BBB score and the inclined plane test, and footprint analysis at 14 days showed more consistent hind limb placement with little stumbling. Histology at day 28 showed significantly attenuated tissue damage and lesion cavit…
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