Single-Dose Escalation Study of SQ-001 Infusion Characterising Astragaloside IV, Calycosin 7-O-beta-glucopyranoside and Lobetyolin Plasma PK
Solid Tumor Refractory to Standard Therapy
Enrolment: 40 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Solid Tumor Refractory to Standard Therapy
Enrolment: 40 · Results not recorded
Joint Discomfort
Enrolment: 50 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Spinal cord injury by T8 laminectomy and vascular clip compression (15 g force) for 1 minute
Astragaloside IV treated rats recovered better than untreated injured rats on BBB score and the inclined plane test, and footprint analysis at 14 days showed more consistent hind limb placement with little stumbling. Histology at day 28 showed significantly attenuated tissue damage and lesion cavit…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Acetaminophen-induced acute liver injury, single oral dose of 400 mg/kg acetaminophen, animals sacrificed 4 h later
Astragaloside IV pre-treatment at 20 and 40 mg/kg significantly reduced serum alanine and aspartate aminotransferase, alleviated necrosis and inflammation on histology, restored hepatic glutathione and superoxide dismutase, lowered malondialdehyde, suppressed TNF-alpha, IL-1beta and IL-6, increased…
Extraction: extract · Supplied extraction confidence: 0.94. Machine-extracted fields require source verification.