TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntravenous, via the tail veinSingle 100 microgram dose of M4P (purified antibody diluted…2 hours after occlusion, that is 1 hour before filament withdrawal and reperfus…
Model: Transient middle cerebral artery occlusion (MCAO) using a silicon coated intraluminal filament, 3 hours of occlusion followed by reperfusion; a permanent MCAO model was used for antibody localisation only
M4P given 1 hour before recanalisation reduced mortality from 20.5% with control IgG to 5%, and reduced total infarct volume from 321 to 188 cubic millimetres, with the largest reductions in the third and fourth brain sections. M4P reduced antibody and Evans Blue extravasation, attenuated the post…
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