THERAPY DOSSIER · th-26a8647f6046

M4P, an affinity purified rabbit polyclonal blocking antibody raised against a 28 amino acid polypeptide in the third extracellular region of rat TRPM4

Biologic · M4P, rabbit polyclonal blocking antibody against TRPM4 third extracellular loop; research antibody.

Evidence & regulatory context

Mechanism: M4P, rabbit polyclonal blocking antibody against TRPM4 third extracellular loop; research antibody.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31664513 ↗2019Reported benefit

TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke.

RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntravenous, via the tail veinSingle 100 microgram dose of M4P (purified antibody diluted…2 hours after occlusion, that is 1 hour before filament withdrawal and reperfus…

Model: Transient middle cerebral artery occlusion (MCAO) using a silicon coated intraluminal filament, 3 hours of occlusion followed by reperfusion; a permanent MCAO model was used for antibody localisation only

M4P given 1 hour before recanalisation reduced mortality from 20.5% with control IgG to 5%, and reduced total infarct volume from 321 to 188 cubic millimetres, with the largest reductions in the third and fourth brain sections. M4P reduced antibody and Evans Blue extravasation, attenuated the post…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…