Pharmacokinetics and anti-inflammatory effect of naproxen in rats with acute and subacute spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntravenous10 mg/kg (single dose)Studied at day 1 (acute) and day 15 (subacute) after spinal cord injury or sham…
Model: Severe contusive spinal cord injury at T9, with a local inflammatory challenge produced by subcutaneous carrageenan injection into forelimb and hindlimb paws
Pharmacokinetics were unchanged by acute injury, but subacute injury altered volume of distribution, clearance and bioavailability with significantly reduced plasma naproxen concentrations. In the subacute stage the anti-inflammatory effect on forelimbs above the injury was similar to sham, but was…
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