THERAPY DOSSIER · th-e6520b0f245c

Naproxen

Drug · Cyclooxygenase inhibitor (INHIBITOR; direct interaction; disease efficacy true)

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Evidence & regulatory context

Mechanism: Cyclooxygenase inhibitor (INHIBITOR; direct interaction; disease efficacy true)
Target: CHEMBL2094253
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 1976
Development stage: Not recorded
ChEMBL record: CHEMBL154 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Naprosyn; Aleve; Anaprox; Naproxen sodium; Naproxeno; Naproxene; NSC-750183; RS-3540; Feminax ultra; Prosaid
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00137033 ↗PHASE4completed

Incidence of Gastroduodenal Ulcers With Celecoxib + Low Dose ASA Versus Naproxen + Low Dose ASA in Healthy Subjects

Peptic Ulcers

Enrolment: 605 · Results not recorded

NCT00222976 ↗PHASE4completed

Oral vs Rectal Administration of Naproxen for Post-Vaginal Perineal Pain Control

Post-Vaginal Delivery Perineal Pain

Enrolment: 60 · Results not recorded

NCT02494856 ↗PHASE4completed

Clinical Efficacy of Naproxen, Associated or Not With Esomeprazole, in Lower Third Molar Removal

Pain · Impacted Third Molar Tooth

Enrolment: 50 · Results not recorded

NCT01147458 ↗PHASE2terminated

5-Lipoxygenase Inhibitor PF-04191834 Alone and In Combination With Naproxen in Flare-Enriched Knee Osteoarthritis

Osteoarthritis, Knee

Enrolment: 190 · Results not recorded

NCT03028870 ↗PHASE2completed

Analgesic Efficacy and Safety of V120083 in Moderate to Severe Chronic Pain Due to Knee Osteoarthritis (naproxen active control)

Osteo Arthritis Knee

Enrolment: 291 · Results not recorded

NCT01102660 ↗PHASE2completed

Pain Relief of PH-797804 Alone Or With Naproxen In Flare-Enriched Knee Osteoarthritis

Osteoarthritis

Enrolment: 172 · Results not recorded

NCT05411718 ↗PHASE2recruiting

Phase IIa Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

T Cells · Colorectal Cancer · Lynch Syndrome

Enrolment: 40 · Results not recorded

NCT00211549 ↗PHASE2completed

Three Doses of IDEA-033 in Comparison to Oral Naproxen for Signs and Symptoms of Knee Osteoarthritis

Osteoarthritis, Knee

Enrolment: 875 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31641817 ↗2019Mixed findings

Pharmacokinetics and anti-inflammatory effect of naproxen in rats with acute and subacute spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntravenous10 mg/kg (single dose)Studied at day 1 (acute) and day 15 (subacute) after spinal cord injury or sham…

Model: Severe contusive spinal cord injury at T9, with a local inflammatory challenge produced by subcutaneous carrageenan injection into forelimb and hindlimb paws

Pharmacokinetics were unchanged by acute injury, but subacute injury altered volume of distribution, clearance and bioavailability with significantly reduced plasma naproxen concentrations. In the subacute stage the anti-inflammatory effect on forelimbs above the injury was similar to sham, but was…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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