Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury.
RatTBIWeight-drop / impact-accelerationSprague-DawleyMalen = 84 rats in total; neuroserpin n = 6 and vehicle n = 6Stereotactic intracerebroventricular injection into the lateral ventricle5 uL of 0.25 mg/mLWithin 20 minutes before injury
Model: Feeney weight-drop traumatic brain injury: 5 mm left parietal craniotomy, 40 g weight dropped from 20 cm onto a 4.5 mm impact tip
Neuroserpin worsened outcome after traumatic brain injury, increasing neurological severity score (14.83 plus or minus 0.31 versus 12.50 plus or minus 0.92), apoptotic cells (49.33 plus or minus 1.86 versus 31.50 plus or minus 1.26) and injured neurons, with greater axonal injury and microglial and…
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