Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Familial Dementia With Neuroserpin Inclusion Bodies · Nervous System Heredodegenerative Disorder
Enrolment: 100 · Results not recorded
Autism
Enrolment: 5 · Results not recorded
Familial Encephalopathy With Neuroserpin Inclusion Bodies · Familial Dementia · Idiopathic Generalised Epilepsy
Enrolment: 176 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Feeney weight-drop traumatic brain injury: 5 mm left parietal craniotomy, 40 g weight dropped from 20 cm onto a 4.5 mm impact tip
Neuroserpin worsened outcome after traumatic brain injury, increasing neurological severity score (14.83 plus or minus 0.31 versus 12.50 plus or minus 0.92), apoptotic cells (49.33 plus or minus 1.86 versus 31.50 plus or minus 1.26) and injured neurons, with greater axonal injury and microglial and…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Clip compression spinal cord injury
Neuroserpin markedly decreased LC3-II and p62 at 72 h after injury, reduced autophagosome accumulation, improved BBB locomotor scores and increased the number of anterior horn motor neurons, indicating restoration of autophagic flux and functional recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Retinal ischaemia/reperfusion induced by cannulating the anterior chamber of the right eye and raising intraocular pressure to 120 mmHg for 60 minutes followed by reperfusion, with the left eye as uninjured control
Neuroserpin pretreatment did not change the acute 24 hour loss of a- and b-waves but produced significantly greater b-wave recovery at 7 days in both wild type (p = 0.02) and tPA-/- mice (p = 0.01). TUNEL-positive cells at 24 hours fell from 25.33 plus or minus 3.21 to 6.67 plus or minus 1.15 per f…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
