Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.

Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.

Model: Lipopolysaccharide challenge to induce sepsis in mice; serum sampling in ICU patients with severe sepsis; lipopolysaccharide stimulation of human peripheral blood mononuclear cells and murine macrophages

Serum agmatine was decreased in patients with sepsis and in lipopolysaccharide-challenged mice. Exogenous agmatine attenuated cytokine production, reduced the inflammatory response and organ damage and lowered the death rate in lipopolysaccharide-induced mice, an effect blocked by the imidazoline I…

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