Nutritional supplementation with agmatine sulfate during small fiber neuropathy
Peripheral Neuropathy
Enrolment: 15 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Peripheral Neuropathy
Enrolment: 15 · Results not recorded
Obstructive Sleep Apnea-hypopnea Syndrome
Enrolment: 90 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Lipopolysaccharide challenge to induce sepsis in mice; serum sampling in ICU patients with severe sepsis; lipopolysaccharide stimulation of human peripheral blood mononuclear cells and murine macrophages
Serum agmatine was decreased in patients with sepsis and in lipopolysaccharide-challenged mice. Exogenous agmatine attenuated cytokine production, reduced the inflammatory response and organ damage and lowered the death rate in lipopolysaccharide-induced mice, an effect blocked by the imidazoline I…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Thoracic contusion spinal cord injury with laminectomy of half of T9 and full T10 and a 10 g rod dropped from 25.0 mm using the MASCIS impactor, under tiletamine/zolazepam and xylazine anaesthesia
By flow cytometry agmatine did not significantly change the proportion of M1 or M2 macrophages one week after injury, although iNOS median fluorescence fell and CD206 rose non-significantly. Immunohistochemistry showed a significant rise in the M2 proportion caudal to the epicentre only, driven by…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.