1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome.
MouseRadiationC57BL/6Male
Model: Whole body irradiation induced haematopoietic injury and abdominal irradiation induced intestinal injury
DTT improved survival of irradiated mice, attenuated whole body irradiation induced myelosuppression and myeloid skewing, increased self-renewal and differentiation of haematopoietic progenitor and stem cells, protected crypt-villus structure and function after abdominal irradiation, and reversed r…
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