THERAPY DOSSIER · th-6fc53d8bef5d

1,4-Dithiothreitol (DTT)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04371068 ↗Phase not recordedcompleted

Evaluation of the microDTTect Device (DTT) in Diagnosis of Low-grade Chronic PJI

Chronic PJIs

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31627170 ↗2019Reported benefit

1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome.

MouseRadiationC57BL/6Male

Model: Whole body irradiation induced haematopoietic injury and abdominal irradiation induced intestinal injury

DTT improved survival of irradiated mice, attenuated whole body irradiation induced myelosuppression and myeloid skewing, increased self-renewal and differentiation of haematopoietic progenitor and stem cells, protected crypt-villus structure and function after abdominal irradiation, and reversed r…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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