Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.
MixedEndotoxin/LPSC57BL/6 mice; Tg(mpx:GFP)i114 zebrafishFemale (C57BL/6 mice in the lipopolysaccharide airway model); not stated for zymosan peritonitis micen = Lipopolysaccharide airway model 8 mice per group; zymosan p…Intraperitoneal injection in mice; bath immersion in zebrafishMice 20 mg/kg in 10% DMSO in vegetable oil; zebrafish 10 uM…Immediately after lipopolysaccharide nebulisation; 4 hours after zymosan inject…
Model: Murine nebulised lipopolysaccharide airway inflammation and zymosan-induced peritonitis; zebrafish tail fin transection
Tyrphostin AG825 increased lung neutrophil apoptosis and macrophage efferocytosis without changing total lavage neutrophil or macrophage numbers, reduced peritoneal inflammatory cell numbers, KC and IgM in zymosan peritonitis, and reduced neutrophil number at the zebrafish injury site while increas…
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