THERAPY DOSSIER · th-649945553ece

Tyrphostin AG825 (also CP-724714, gefitinib and erbstatin)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00055926 ↗PHASE1completed

Phase I Safety and Pharmacokinetic/Pharmacodynamic Study of CP-724,714 In Patients With Metastatic HER2-Overexpressing Breast Cancer

Breast Cancer

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31613219 ↗2019Mixed findings

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.

MixedEndotoxin/LPSC57BL/6 mice; Tg(mpx:GFP)i114 zebrafishFemale (C57BL/6 mice in the lipopolysaccharide airway model); not stated for zymosan peritonitis micen = Lipopolysaccharide airway model 8 mice per group; zymosan p…Intraperitoneal injection in mice; bath immersion in zebrafishMice 20 mg/kg in 10% DMSO in vegetable oil; zebrafish 10 uM…Immediately after lipopolysaccharide nebulisation; 4 hours after zymosan inject…

Model: Murine nebulised lipopolysaccharide airway inflammation and zymosan-induced peritonitis; zebrafish tail fin transection

Tyrphostin AG825 increased lung neutrophil apoptosis and macrophage efferocytosis without changing total lavage neutrophil or macrophage numbers, reduced peritoneal inflammatory cell numbers, KC and IgM in zymosan peritonitis, and reduced neutrophil number at the zebrafish injury site while increas…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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