Vitamin E protects against monosodium glutamate-induced acute liver injury and hepatocyte ultrastructural alterations in rats.
RatChemical/toxinSprague-Dawley100 mg/kg or 300 mg/kgGiven together with monosodium glutamate across the 7-day exposure period
Model: Monosodium glutamate-induced acute liver injury, 4 g/kg daily for 7 days, with sacrifice on day 8
Monosodium glutamate produced apoptotic hepatocytes with pyknotic nuclei, cytoplasmic vacuolation, swollen mitochondria, dilated endoplasmic reticulum and sinusoids, and collagen deposition. Vitamin E at 300 mg/kg substantially preserved liver tissue and hepatocellular architecture, with only parti…
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