PRECLINICAL PUBLICATION · 2019

A feasible biocompatible hydrogel film embedding Periplaneta americana extract for acute wound healing.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Periplaneta americana extract embedded in a hydrogel film (PAE/Film) cast from polyvinyl alcohol, hydroxypropyl chitosan and carbomer at a weight ratio of 78/6/3 with glycerol as plasticiser

PMID 31593807 ↗2019Reported benefit

A feasible biocompatible hydrogel film embedding Periplaneta americana extract for acute wound healing.

MouseWoundMaleTopical

Model: Full-thickness skin defect and scald wound models

The extract-loaded hydrogel film significantly accelerated wound healing in both the full-thickness skin defect and scald models relative to saline, blank film and free extract, and promoted re-epithelialisation and collagen deposition through TGF-beta/Smad pathway activation.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.