THERAPY DOSSIER · th-7803f1bb5873

Periplaneta americana extract embedded in a hydrogel film (PAE/Film) cast from polyvinyl alcohol, hydroxypropyl chitosan and carbomer at a weight ratio of 78/6/3 with glycerol as plasticiser

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07353671 ↗PHASE2/PHASE3recruiting

Topical Periplaneta Americana-Derived Regenerative Solution for Radiation Dermatitis

Radiation-induced Dermatitis

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31593807 ↗2019Reported benefit

A feasible biocompatible hydrogel film embedding Periplaneta americana extract for acute wound healing.

MouseWoundMaleTopical

Model: Full-thickness skin defect and scald wound models

The extract-loaded hydrogel film significantly accelerated wound healing in both the full-thickness skin defect and scald models relative to saline, blank film and free extract, and promoted re-epithelialisation and collagen deposition through TGF-beta/Smad pathway activation.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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