Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing.
RatOtherSprague-DawleyMaleLocal implantation at the tendon-to-bone interfaceImplanted at the time of rotator cuff repair
Model: Acute rotator cuff tear model with tendon-to-bone (enthesis) repair; parallel in vitro long-term chondroid pellet model using human bone marrow-derived mesenchymal stem cells
Melatonin-loaded polycaprolactone membranes inhibited macrophage infiltration at the tendon-to-bone interface in the early healing phase, increased chondroid zone formation, promoted collagen maturation, decreased fibrovascular tissue formation and improved the biomechanical strength of the regener…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.