Topically Applied Melatonin-loaded Gelatin Sponge on Palatal Wound Healing
Wound Healing
Enrolment: 26 · Results not recorded
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Drug · Melatonin receptor agonist (AGONIST); active at MT1, MT2 and MT3 receptors, MT1/MT2 most relevant; sleep promoting activity.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Wound Healing
Enrolment: 26 · Results not recorded
Obesity · Prediabetic State
Enrolment: 120 · Results not recorded
Orthopedic Surgery
Enrolment: 357 · Results not recorded
Aortic Aneurysm
Enrolment: 52 · Results not recorded
Multiple Sclerosis, Relapsing-Remitting
Enrolment: 25 · Results not recorded
Bioavailability
Enrolment: 12 · Results not recorded
Antioxidants · Oxidative Stress · Inflammation · Lipid Peroxidation
Enrolment: 81 · Results not recorded
Cervical Cancer · Radiotherapy Side Effect
Enrolment: 71 · Results not recorded
Disorder of Consciousness
Enrolment: 90 · Results not recorded
Circadian Rhythm Sleep Disorder, Jet Lag Type
Enrolment: 36 · Results not recorded
24 studies reported at therapy level; 31 evidence entries itemised.
Model: Renal ischaemia-reperfusion injury, 1 hour ischaemia followed by 72 hours reperfusion
Kidney injury score, plasma creatinine and blood urea nitrogen were highest in the untreated ischaemia-reperfusion group and lowest in sham, significantly higher in each monotherapy group than in the combined group, and significantly higher with exendin-4 alone than with melatonin alone (all p < 0.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Myocardial ischaemia-reperfusion injury in vivo and ex vivo (isolated heart)
Chronic moderate red wine consumption reduced infarct size in both rats and wild-type mice (p < 0.001). Luzindole did not affect the protection whereas prazosin reduced the infarct sparing effect (p < 0.05), and neither red wine nor melatonin protected TNF receptor 2 knockout or cardiomyocyte-speci…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Controlled cortical impact (1.5 mm) traumatic brain injury
Neither melatonin, minocycline nor their combination significantly improved cognitive or histological outcomes after TBI.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Three models: local hind-limb injection of alpha-latrotoxin (5 microgram/kg) causing reversible presynaptic motor terminal degeneration; sciatic nerve crush (haemostatic forceps for 20 s, 0.5 cm from hip insertion); sciatic nerve transection with edges left juxtaposed
Melatonin accelerated recovery of neurotransmission after alpha-latrotoxin injury and after sciatic crush, with significantly greater compound muscle action potential recovery at 18 and 26 days and complete recovery by 26 days, and increased axonal regrowth after transection with Schwann cell proli…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Acute spinal cord injury model in mice
Melatonin reduced reactive gliosis, proinflammatory cytokine expression and oxidative stress, and improved Basso mouse scale locomotor scores after spinal cord injury.
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Model: Lipopolysaccharide-induced maternal inflammation in pregnant mice causing preterm birth and perinatal fetal brain injury
Melatonin pre-treatment lowered proinflammatory cytokines in the uterus and placenta, significantly improved lipopolysaccharide-induced acute fetal neuroinflammation and perinatal brain injury, and significantly upregulated SIRT1/Nrf2 signalling. It decreased preterm birth and prevented adverse neu…
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Model: Doxorubicin-induced acute cardiotoxicity by intraperitoneal doxorubicin 18 mg/kg daily for three days
Pretreatment with melatonin, agomelatine or both normalised doxorubicin-induced electrocardiographic abnormalities and reduced serum creatine kinase, troponin T and 99mTc pyrophosphate uptake.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute contusion spinal cord injury
Melatonin-treated rats showed higher BBB locomotor scores, smaller spinal cavities and less cleaved caspase 3 staining than vehicle controls, with decreased M1 and increased M2 microglial/macrophage markers and reduced TNF-alpha, IL-6 and IL-1beta in injured spinal cord.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Carbon tetrachloride-induced acute kidney injury
Both regimens preserved kidney function on standard serum parameters and prevented the carbon tetrachloride-induced rise in tissue KIM-1, matching the morphological findings. Only post-intoxication melatonin preserved total kidney antioxidant capacity, while pre-treatment preserved reduced glutathi…
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Model: Acute doxorubicin induced cardiotoxicity, doxorubicin 20 mg/kg cumulative dose in vivo and 1 micromolar doxorubicin in H9c2 cells
Melatonin markedly alleviated doxorubicin-induced acute cardiac dysfunction and myocardial injury, inhibited mitochondrial dysfunction and morphological disorder, apoptosis and oxidative stress, through AMPK activation and PGC1alpha upregulation. These effects were reversed by AMPK or PGC1alpha siR…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Chronic intracortical microelectrode implantation injury in visual cortex, 3 mm single-shank planar silicon probe (NeuroNexus A1x16-3MM-100-703-CM15), followed for 16 weeks
Chronic daily melatonin maintained significantly higher single-unit yield, signal-to-noise ratio and amplitude than saline across 16 weeks and outperformed acute dosing from week 4 onward, with about 49 per cent more neurons at 0 to 10 micrometres, 70 per cent fewer caspase-3 positive neurons at 10…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Heat stroke induced by exposing anaesthetised rats to an ambient temperature of 43 degrees C for 70 min, causing hyperthermia, hypotension and myocardial injury
Pretreatment with melatonin significantly reversed heat stroke-induced myocardial injury, cardiac oxidative stress and cardiac inflammation.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Full-thickness dermal burn covering 40% total body surface area produced by immersing the shaved back in 98 degrees C water for 15 s, with lactated Ringer resuscitation
Melatonin reduced burn-induced glomerular necrosis and tubular casts, lowered serum creatinine and blood urea nitrogen, cut malondialdehyde while restoring superoxide dismutase and glutathione, reduced TNF-alpha, IL-1beta and ICAM-1 and raised IL-10, lowered Bax, cleaved caspase-3 and TUNEL apoptos…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Pulmonary contusion induced by isolated blunt thoracic trauma
On day 2 melatonin lowered malondialdehyde and total oxidant capacity, raised total antioxidant capacity, improved blood gases and liver and kidney biochemistry, and reduced histological damage scores relative to untreated trauma.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Exercise-induced skeletal muscle damage and inflammation from swimming to exhaustion at the individually determined anaerobic threshold intensity, in light or dark circadian periods
Melatonin was strongly ergogenic, increasing time to exhaustion (the nocturnal melatonin group swam 155.84% longer than nocturnal vehicle), but it did not prevent exercise-induced inflammation or muscle damage, and CK-MM and LDH were higher with melatonin, which the authors attributed to the longer…
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Model: Laminectomy followed by spinal cord compression injury in rats
Melatonin at 100 mg/kg left spinal cord water content essentially unchanged at 12 h but significantly reduced it from 24 to 72 h, and decreased aquaporin-4 and GFAP expression between 24 and 72 h after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute spinal cord injury in mice (model details not stated in the abstract)
Melatonin at 50 mg/kg given immediately after spinal cord injury reduced blood spinal cord barrier permeability, limited microvessel loss and oedema, preserved tight junction proteins, endothelial cells and pericytes, and lowered apoptosis and MMP3, AQP4, HIF-1alpha, VEGF and VEGFR2 expression.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.
Model: Thermal (burn) injury in rats with intravital microscopy of venules, and burn serum applied to rat lung microvascular endothelial cell monolayers
Burn increased vascular hyperpermeability, and burn serum increased monolayer permeability, adherens junction damage, stress fibre formation and reactive oxygen species generation. Melatonin attenuated each of these effects.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Whole-body gamma irradiation at 9.5-10.0 Gy delivered at 7.7-17.1 cGy/min, approximately LD97/30
Melatonin improved survival by more than 20 percent, reduced leukopenia at the peak of illness and increased blood leukocyte count by about 40 percent by day 12.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Systemic lipopolysaccharide (2 mg/kg intraperitoneal, serotype 055:B5) induced neonatal brain injury
Melatonin shortened the lipopolysaccharide-induced increase in righting reflex latency and limited the fall in wire-hanging latency, attenuated loss of O4 positive oligodendrocytes and axonal amyloid precursor protein accumulation, prevented the fall in mitochondrial complex I activity, and reduced…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis with associated lung injury induced by infusion of 1 mL/kg sodium taurocholate 4 per cent solution into the biliopancreatic duct
Melatonin given 30 min before taurocholate-induced severe acute pancreatitis lowered pancreatic pathological scores at all time points and restored lung interleukin 22 and T helper 22 mRNA levels relative to untreated animals.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Heatstroke induced by exposing anaesthetised rats to heat stress at 36 degrees C for 100 min, followed by recovery at 26 degrees C, causing acute lung inflammation and injury
Melatonin at 1 and 5 mg/kg prolonged survival time to 117 and 186 min compared with 59 min in vehicle treated rats, attenuated hyperthermia and hypotension, reduced lung oedema, neutrophil infiltration and haemorrhage, lowered TNF-alpha, IL-1 beta and IL-6 while raising IL-10, and reduced bronchoal…
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Model: Acute rotator cuff tear model with tendon-to-bone (enthesis) repair; parallel in vitro long-term chondroid pellet model using human bone marrow-derived mesenchymal stem cells
Melatonin-loaded polycaprolactone membranes inhibited macrophage infiltration at the tendon-to-bone interface in the early healing phase, increased chondroid zone formation, promoted collagen maturation, decreased fibrovascular tissue formation and improved the biomechanical strength of the regener…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Acute sodium fluoride intoxication (48 mg/kg body weight, single oral gavage) causing hepatic and pulmonary oxidative injury
Vesicular melatonin given 2 h after NaF reversed the rise in ROS, lipid peroxidation, NADH oxidase activity, TNF-alpha and TGF-beta, and restored antioxidant enzymes, membrane potential and microviscosity in liver and lung. Nanoencapsulated melatonin was most effective, followed by charge-specific…
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