Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage.
Model: Polytrauma consisting of laparotomy, three crush injuries to each of the left and medial liver lobes, ten crush injuries to a 10 cm section of small intestine at the proximal cecum, a closed right femur fracture produced by dropping six 65 g steel balls from 36 inches through a guide tube, and ten crushes of right leg skeletal muscle; followed by haemorrhage to a mean arterial pressure of 40 mmHg until 40 per cent of estimated blood volume was removed. All groups received limited fresh whole blood resuscitation at 60 min after trauma (20 per cent of blood volume, 50 per cent of shed volume).
Tranexamic acid given before trauma inhibited the rise in prothrombin time at 30 min, delaying the onset of acute traumatic coagulopathy from 30 to 120 min, and significantly lowered plasma D-dimer and the plasmin(ogen)/fibrin(ogen) ratio in traumatised liver relative to vehicle and to tranexamic a…
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