Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury.
RatTBIFluid percussionSprague-Dawleymalen = n=10 sham plus vehicle, n=8 sham plus AVL-3288, n=11 injure…Intraperitoneal in vivo; bath application in vitro0.3 mg/kg in vivo; 1 microM bath application to hippocampal…Chronic phase, beginning 3 months after injury, with each dose given 30 min bef…
Model: Moderate parasagittal fluid-percussion brain injury (1.9 plus or minus 0.1 atm, 14 to 16 msec pulse) to the right parietal cortex, with sham surgery controls
AVL-3288 improved cue and contextual fear memory at 24 h and 1 month, water maze retention and working memory in injured rats, modestly reduced hippocampal but not cortical atrophy, and rescued CA1 basal synaptic transmission and long-term potentiation.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.