THERAPY DOSSIER · th-09f4693dee95

AVL-3288

Drug · Neuronal acetylcholine receptor alpha-7 subunit positive allosteric modulator (Type I PAM; direct interaction; disease efficacy true)

Not approved Suggest a correction

Evidence & regulatory context

Mechanism: Neuronal acetylcholine receptor alpha-7 subunit positive allosteric modulator (Type I PAM; direct interaction; disease efficacy true)
Target: CHEMBL2492
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL429317 ↗
ChEMBL max phase: 1 / 4 (development scale, not regulatory approval)
Synonyms: Anvylic-3288; Avl-3288; CCMI; UCI-4083; XY-4083
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03281694 ↗PHASE1withdrawn

The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine

Cognitive Change

Enrolment: 0 · Results not recorded

NCT01851603 ↗PHASE1terminated

Phase I Dose Escalating Study of Safety, Tolerability and PK of Single Oral Doses of AVL-3288 in Healthy Subjects

Schizophrenia

Enrolment: 12 · Results not recorded

NCT02978599 ↗PHASE1completed

Two Dose Cross-over Trial of the alpha7 Nicotinic PAM AVL-3288 in Schizophrenia Patients

Schizophrenia · Schizoaffective Disorder

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31581202 ↗2019Reported benefit

Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury.

RatTBIFluid percussionSprague-Dawleymalen = n=10 sham plus vehicle, n=8 sham plus AVL-3288, n=11 injure…Intraperitoneal in vivo; bath application in vitro0.3 mg/kg in vivo; 1 microM bath application to hippocampal…Chronic phase, beginning 3 months after injury, with each dose given 30 min bef…

Model: Moderate parasagittal fluid-percussion brain injury (1.9 plus or minus 0.1 atm, 14 to 16 msec pulse) to the right parietal cortex, with sham surgery controls

AVL-3288 improved cue and contextual fear memory at 24 h and 1 month, water maze retention and working memory in injured rats, modestly reduced hippocampal but not cortical atrophy, and rescued CA1 basal synaptic transmission and long-term potentiation.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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