Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
MouseChemical/toxinC57BL/6Male
Model: Doxorubicin-induced acute cardiotoxicity in mice, with parallel doxorubicin exposure of H9C2 cardiomyoblasts in vitro
Doxorubicin caused acute cardiac injury with reduced cardiac function, increased cardiomyocyte apoptosis and a significant rise in CACNA1H expression. ABT-639 partly protected myocardial function and reduced cardiomyocyte apoptosis, and significantly changed endoplasmic reticulum stress-related pro…
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