Electrophysiological Effects of ABT-639 on Spontaneous Activity in C-Nociceptors in Painful Diabetic Peripheral Neuropathy
Diabetic Neuropathic Pain
Enrolment: 39 · Results not recorded
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Drug · Voltage-gated T-type calcium channel alpha-1H subunit blocker (BLOCKER; direct interaction; disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Diabetic Neuropathic Pain
Enrolment: 39 · Results not recorded
Diabetic Neuropathic Pain
Enrolment: 193 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Doxorubicin-induced acute cardiotoxicity in mice, with parallel doxorubicin exposure of H9C2 cardiomyoblasts in vitro
Doxorubicin caused acute cardiac injury with reduced cardiac function, increased cardiomyocyte apoptosis and a significant rise in CACNA1H expression. ABT-639 partly protected myocardial function and reduced cardiomyocyte apoptosis, and significantly changed endoplasmic reticulum stress-related pro…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.