N-acetylcysteine and atorvastatin alleviates lung injury due to ischemia-reperfusion injury in rats.
RatIschaemia-reperfusionIntestinal / mesentericSprague DawleyMalen = 30 male rats in total, n = 6 per group across five groupsAtorvastatin by oral gavage; N-acetylcysteine by intraperitoneal injectionAtorvastatin 40 mg/kg body weight per day; N-acetylcysteine…Pretreatment for 3 days before surgery, with the final dose given 12 hours befo…
Model: Superior mesenteric artery occlusion for 60 minutes followed by 60 minutes of reperfusion, with remote acute lung injury as the readout
All pretreatment groups showed lower neutrophil to lymphocyte ratio, lactate and alanine aminotransferase and lower lung tissue TNF-alpha than the untreated ischaemia-reperfusion group. Only the combined atorvastatin plus N-acetylcysteine group showed significantly lower creatinine, alkaline phosph…
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