Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice.
MouseChemical/toxinMale200 mg/kgGiven as pretreatment before manganese intoxication
Model: Sub-acute manganese intoxication (manganism) induced with manganese at 30 mg/kg
Manganese intoxication reduced distance travelled by 46 percent, mean speed by 36 percent and rotarod performance to 42 percent, and lowered the weights test score, alongside disrupted tyrosine hydroxylase immunoreactivity in the nigrostriatal pathway. Pretreatment with docosahexaenoic acid maintai…
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