Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase.

Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase.

Model: Contrast-induced nephropathy induced with iohexol, with parallel in vitro studies in HK-2 proximal tubular cells

Febuxostat attenuated renal impairment and tubular injury in the mouse contrast-induced nephropathy model and reduced plasma and kidney xanthine oxidoreductase. It enhanced AMPK phosphorylation and inhibited Nox1, Nox2 and HIF-1alpha, lowering reactive oxygen species in vivo and in vitro and reduci…

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