Diacerein Combined With Febuxostat Relieves Symptoms of Gout by Suppressing IL-1beta Inflammation
Primary Gout
Enrolment: 96 · Results not recorded
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Drug · Non-purine selective xanthine oxidase/dehydrogenase inhibitor; lowers urate production. ChEMBL mec_id 438, INHIBITOR, direct interaction, disease efficacy true (DailyMed ref). ATC M04AA03. Black box warning (cardiovascular death, CARES trial).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Primary Gout
Enrolment: 96 · Results not recorded
Gout
Enrolment: 196 · Results not recorded
Hyperuricemia
Enrolment: 50 · Results not recorded
Adenine Phosphoribosyltransferase Deficiency
Enrolment: 9 · Results not recorded
Gout
Enrolment: 1072 · Results not recorded
Gout
Enrolment: 116 · Results not recorded
Gout · Moderate Renal Impairment
Enrolment: 189 · Results not recorded
Hyperuricemia
Enrolment: 28 · Results not recorded
Chronic Kidney Disease · Hyperuricemia · Abnormal Renal Function
Enrolment: 160 · Results not recorded
Gout
Enrolment: 60 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Contrast-induced nephropathy induced with iohexol, with parallel in vitro studies in HK-2 proximal tubular cells
Febuxostat attenuated renal impairment and tubular injury in the mouse contrast-induced nephropathy model and reduced plasma and kidney xanthine oxidoreductase. It enhanced AMPK phosphorylation and inhibited Nox1, Nox2 and HIF-1alpha, lowering reactive oxygen species in vivo and in vitro and reduci…
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Model: Paraquat-induced acute lung toxicity following a single intraperitoneal dose of paraquat 30 mg/kg
Febuxostat attenuated paraquat-induced lung injury by inhibiting xanthine oxidase activity and associated oxidative stress, downregulating the RAGE/PI3K/Akt pathway and suppressing beta-catenin and its downstream inflammatory mediators.
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Model: Acid-induced acute lung injury with 75 microlitres of hydrochloric acid buffered in 0.02 M citric acid instilled intratracheally, acetaminophen liver injury at 300 mg/kg intraperitoneally after overnight fast, and zymosan peritonitis with 100 micrograms intraperitoneally as a control stimulus
Febuxostat lowered serum, lung and liver uric acid and reduced neutrophilic inflammation after acid lung injury and acetaminophen liver injury, but did not reduce zymosan peritonitis, indicating it is not a general anti-inflammatory.
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.