A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response.
MouseChemical/toxinC57BL/6
Model: Dextran sodium sulfate-induced acute colitis, with parallel Caco2 in vitro wound healing model and human inflammatory bowel disease colon explants
CTB-KDEL induced an unfolded protein response and promoted colon epithelial restitution and wound healing in dextran sodium sulfate colitis, with matching unfolded protein response induction, upregulated wound healing pathways and maintained crypt viability in human inflammatory bowel disease expla…
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