THERAPY DOSSIER · th-e5f77d8df702

CTB-KDEL, a recombinant cholera toxin B subunit carrying an endoplasmic reticulum retention motif

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31560862 ↗2019Reported benefit

A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response.

MouseChemical/toxinC57BL/6

Model: Dextran sodium sulfate-induced acute colitis, with parallel Caco2 in vitro wound healing model and human inflammatory bowel disease colon explants

CTB-KDEL induced an unfolded protein response and promoted colon epithelial restitution and wound healing in dextran sodium sulfate colitis, with matching unfolded protein response induction, upregulated wound healing pathways and maintained crypt viability in human inflammatory bowel disease expla…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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