Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning.
MouseChemical/toxinKunmingmalen = n=10 per group across three groups; TNF-alpha figure legend…Intraperitoneal injection100 mg/kgAfter intragastric paraquat administration, starting the same day
Model: Acute lung injury from paraquat poisoning by single intragastric dose of paraquat 25 mg/kg
1-methylhydantoin lowered lung malondialdehyde and TNF-alpha relative to paraquat alone and shifted lung metabolite profiles, but superoxide dismutase and lactate dehydrogenase activities did not differ significantly from the paraquat group.
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