THERAPY DOSSIER · th-47809c9c119d

1-methylhydantoin

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31560695 ↗2019Mixed findings

Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning.

MouseChemical/toxinKunmingmalen = n=10 per group across three groups; TNF-alpha figure legend…Intraperitoneal injection100 mg/kgAfter intragastric paraquat administration, starting the same day

Model: Acute lung injury from paraquat poisoning by single intragastric dose of paraquat 25 mg/kg

1-methylhydantoin lowered lung malondialdehyde and TNF-alpha relative to paraquat alone and shifted lung metabolite profiles, but superoxide dismutase and lactate dehydrogenase activities did not differ significantly from the paraquat group.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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