alpha-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation.
MouseChemical/toxinC57BL/6J wild-type; NLRP3-deficient mice on C57BL/6N background with wild-type littermatesmalesubcutaneous5 mg/kg30 min before phenylephrine injection
Model: Phenylephrine-induced alpha-adrenergic receptor overactivation causing acute cardiac inflammation and dysfunction; Langendorff-perfused hearts and cultured cardiomyocytes treated with phenylephrine 10 microM
Prazosin pretreatment blocked phenylephrine-induced cardiac dysfunction, macrophage infiltration and proinflammatory cytokine and chemokine upregulation, and the inflammatory response was absent in NLRP3-deficient mice, indicating alpha-AR overactivation drives cardiac inflammation via NLRP3 inflam…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.