Noradrenergic Biomarkers in PTSD: Prazosin Precision Medicine
Posttraumatic Stress Disorder
Enrolment: 87 · Results not recorded
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Drug · Adrenergic receptor alpha-1 antagonist
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Posttraumatic Stress Disorder
Enrolment: 87 · Results not recorded
Stress Disorders, Post-Traumatic · Bulimia Nervosa
Enrolment: 9 · Results not recorded
Stress Disorders, Post-Traumatic · Combat Disorders · Sleep Disorders
Enrolment: 67 · Results not recorded
Alzheimer's Disease
Enrolment: 20 · Results not recorded
Alcohol Use Disorder
Enrolment: 36 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Phenylephrine-induced alpha-adrenergic receptor overactivation causing acute cardiac inflammation and dysfunction; Langendorff-perfused hearts and cultured cardiomyocytes treated with phenylephrine 10 microM
Prazosin pretreatment blocked phenylephrine-induced cardiac dysfunction, macrophage infiltration and proinflammatory cytokine and chemokine upregulation, and the inflammatory response was absent in NLRP3-deficient mice, indicating alpha-AR overactivation drives cardiac inflammation via NLRP3 inflam…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.