HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk.
MouseIschaemia-reperfusionRenalmaleintraperitoneal1 day (24 h) before renal ischaemia-reperfusion surgery
Model: Bilateral renal ischaemia-reperfusion for 26 min, with sham surgery controls, and secondary acute lung injury
Hemin-induced heme oxygenase-1 reduced renal damage, renal inflammation and oxidative stress after ischaemia-reperfusion, dampened systemic IL-6 and KC, and mitigated downstream lung inflammation including neutrophil influx and lung KC.
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