Pre-treatment With Haem Arginate (Normosang) on Heme-Oxygenase 1 Upregulation in Deceased Donor Kidney Recipients
Graft Failure · Ischemia-reperfusion Injury
Enrolment: 40 · Results not recorded
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Drug
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Graft Failure · Ischemia-reperfusion Injury
Enrolment: 40 · Results not recorded
Gastroparesis · Diabetes Mellitus
Enrolment: 20 · Results not recorded
Acute Intermittent Porphyria · Hereditary Coproporphyria · Variegate Porphyria
Enrolment: 13 · Results not recorded
Myelodysplastic Syndrome
Enrolment: 6 · Results not recorded
Healthy Volunteers
Enrolment: 10 · Results not recorded
Acute Intermittent Porphyria · Hereditary Coproporphyria · Variegate Porphyria
Enrolment: 50 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Traumatic spinal cord injury produced by trauma
Heme oxygenase activity increased after injury at all times measured and was raised 7.2-fold at 24 h by hemin compared with injury plus vehicle. Rats treated with hemin at 2 h and 8 h showed better motor recovery and more spared cord tissue, indicating that heme oxygenase activation is beneficial i…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Bilateral renal ischaemia-reperfusion for 26 min, with sham surgery controls, and secondary acute lung injury
Hemin-induced heme oxygenase-1 reduced renal damage, renal inflammation and oxidative stress after ischaemia-reperfusion, dampened systemic IL-6 and KC, and mitigated downstream lung inflammation including neutrophil influx and lung KC.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: L-arginine-induced acute pancreatitis with associated lung injury
Hemin given before induction significantly attenuated the rise in serum amylase, lipase, tumour necrosis factor alpha and nitric oxide, compensated the deficit in total antioxidant capacity, lowered malondialdehyde and improved pancreatic and pulmonary histology. Hemin given after induction showed…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.