PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2019

Pioglitazone improves working memory performance when administered in chronic TBI.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 31513844 ↗2019Reported benefit

Pioglitazone improves working memory performance when administered in chronic TBI.

RatTBIFluid percussionSprague-DawleymaleTreatment started 46 days after lateral fluid percussion injury

Model: Lateral fluid percussion traumatic brain injury

Pioglitazone started 46 days after injury improved radial arm maze working memory to a level similar to controls and increased hippocampal hexokinase activity, without changing glucose transporter, hexokinase, GFAP or Iba-1 expression.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.