PPAR-gamma: a Novel Therapeutic Target in Asthma?
Asthma
Enrolment: 68 · Results not recorded
Loading the evidence…
Drug · Peroxisome proliferator-activated receptor gamma agonist (AGONIST); direct interaction, disease efficacy true; thiazolidinedione insulin sensitiser. Black box warning present.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Asthma
Enrolment: 68 · Results not recorded
Diabetes Mellitus, Type 2
Enrolment: 978 · Results not recorded
Coronary Artery Disease · Type 2 Diabetes Mellitus
Enrolment: 38 · Results not recorded
Diabetes Mellitus, Type 2
Enrolment: 400 · Results not recorded
Chronic Myeloid Leukemia (CML)
Enrolment: 26 · Results not recorded
Healthy
Enrolment: 36 · Results not recorded
Polycystic Ovary Syndrome
Enrolment: 90 · Results not recorded
Diabetes Mellitus, Type 2
Enrolment: 593 · Results not recorded
Alcohol Use Disorder
Enrolment: 201 · Results not recorded
Psoriasis
Enrolment: 48 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Myocardial ischaemia-reperfusion injury and permanent left anterior descending artery ligation myocardial infarction
Pioglitazone nanoparticles attenuated ischaemia-reperfusion injury, reduced inflammatory monocyte recruitment, promoted M2 macrophage polarisation, attenuated cardiac remodelling and decreased mortality after myocardial infarction, with cardioprotection confirmed in a conscious porcine model. Free…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Lateral fluid percussion traumatic brain injury
Pioglitazone started 46 days after injury improved radial arm maze working memory to a level similar to controls and increased hippocampal hexokinase activity, without changing glucose transporter, hexokinase, GFAP or Iba-1 expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Rhabdomyolysis-induced acute kidney injury by intramuscular injection of 50% glycerol 10 mL/kg divided between both hind limbs, with water deprivation for 24 h beforehand; animals killed 24 h after glycerol
Glycerol raised serum creatinine to 3.447 mg/dL and urea to 146.3 mg/dL and depleted glutathione to 1.404 mg/g. Pioglitazone reduced creatinine to 2.39 mg/dL (3 days) and 2.072 mg/dL (6 days) and raised glutathione, with no significant difference between the 3-day and 6-day regimens.
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Severe mid-thoracic contusion spinal cord injury, T9 laminectomy and Infinite Horizons impactor at 75 kdyn (achieved force approximately 78 kdyn); sham was laminectomy only
Pioglitazone preserved acute mitochondrial respiration near sham levels and, with 5 days of daily dosing, improved locomotor recovery and increased grey and white matter sparing, but did not reduce chronic microglial and macrophage IBA-1 immunoreactivity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Moderate midline fluid percussion brain injury (diffuse traumatic brain injury), with sham controls
Pioglitazone attenuated microglial activation and improved dopaminergic neuronal survival in the nigrostriatal system after diffuse traumatic brain injury, with reported improvement in locomotor recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.