Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Liver Regeneration After Ischemia Reperfusion Injury in Mice.
MouseIschaemia-reperfusionHepaticSystemic administrationBefore hepatic ischaemia-reperfusion
Model: Hepatic ischaemia-reperfusion injury
MSCs and MSC-derived extracellular vesicles lowered serum transaminases, reduced hepatic necrosis, increased Ki67-positive hepatocytes and repressed inflammatory gene transcription; fibroblast-derived vesicles showed only late regenerative effects.
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