Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Radiation · Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 9
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease?
Safety Issues · Efficacy
Enrolment: 50 · Results not recorded
The Effect of Mesenchymal Stromal Cells on the Mortality of Patients With Sepsis and Septic Shock: A Promising Therapy
Sepsis · Septic Shock
Enrolment: 30 · Results not recorded
A Phase I/II Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Efficacy of VUM02 Injection in the Treatment of Patients With Steroid-refractory Acute Graft-versus-host Disease (SR-aGvHD)
Steroid-refractory Acute Graft-versus-host Disease
Enrolment: 149 · Results not recorded
Allogeneic Adipose Tissue Derived Mesenchymal Stromal Cell Therapy for Treating Patients With Severe Respiratory COVID-19. A Danish, Double-blind, Randomized Placebo-controlled Study
Respiratory Tract Diseases
Enrolment: 0 · Results not recorded
The Safety and Efficacy Assessment of Collagen Membrane Combined With Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Patients With Nasal Septum Perforation
Chronic Nasal Septum Perforation
Enrolment: 12 · Results not recorded
Phase I Study of Intramuscular (IM) Injections of Allogeneic PLX-PAD Cells for the Treatment of Critical Limb Ischemia. PLX-PAD Are Mesenchymal-Like Stromal Cells Derived From a Full Term Placenta.
Peripheral Artery Disease · Peripheral Vascular Disease · Critical Limb Ischemia
Enrolment: 12 · Results not recorded
A Randomized Trial to Elucidate Effect of Mesenchymal Stem Cells on Immune Modulation in Living Related Kidney Transplant Patients
Renal Transplant Rejection
Enrolment: 17 · Results not recorded
Safety and Efficacy Study of Autologous Adipose Derived Mesenchymal Stem Cells Implantation in Chronic Low Back Pain Patients With Lumbar Intervertebral Disc Degeneration
Low Back Pain
Enrolment: 10 · Results not recorded
Efficacy and Safety of Different Transplantation Routes of Human Umbilical Cord-mesenchymal Stem Cells in Patients With End-stage Liver Disease
End-Stage Liver Diseases
Enrolment: 32 · Results not recorded
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseRadiationIntravenous transplantationAfter irradiation
Model: Lethal total body irradiation (acute radiation syndrome)
Intravenous MSCs without HSC support conferred long-term survival and rapid haematopoietic recovery after lethal irradiation via trophic and niche-modulating effects.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
MouseIschaemia-reperfusionHepaticSystemic administrationBefore hepatic ischaemia-reperfusion
Model: Hepatic ischaemia-reperfusion injury
MSCs and MSC-derived extracellular vesicles lowered serum transaminases, reduced hepatic necrosis, increased Ki67-positive hepatocytes and repressed inflammatory gene transcription; fibroblast-derived vesicles showed only late regenerative effects.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
