Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling.
MouseChemical/toxinMalePretreatment before acetaminophen
Model: Acetaminophen-induced acute kidney injury (with HK-2 cell model in vitro)
SDAPR, SDAP1 and SDAP2 pretreatment dose-dependently attenuated kidney injury markers and tubular histological damage, reduced apoptosis and oxidative stress, activated Nrf2 and inhibited FoxO1; protection was abolished by the PI3K inhibitor LY294002 in HK-2 cells.
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