THERAPY DOSSIER · th-6a894071cb00

Sika deer antler protein (SDAPR) and its fractions SDAP1 and SDAP2

Nutraceutical · Sika-deer antler protein and fractions (SDAP1/2); animal-derived protein extract.

Evidence & regulatory context

Mechanism: Sika-deer antler protein and fractions (SDAP1/2); animal-derived protein extract.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31479670 ↗2019Reported benefit

Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling.

MouseChemical/toxinMalePretreatment before acetaminophen

Model: Acetaminophen-induced acute kidney injury (with HK-2 cell model in vitro)

SDAPR, SDAP1 and SDAP2 pretreatment dose-dependently attenuated kidney injury markers and tubular histological damage, reduced apoptosis and oxidative stress, activated Nrf2 and inhibited FoxO1; protection was abolished by the PI3K inhibitor LY294002 in HK-2 cells.

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

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