In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy.
MouseOtherC57BL/6Malen = Histology n = 4 joints per group; FACE analyses initially n…Injection into the retrocalcaneal bursa24 h after induction of injury
Model: Retrocalcaneal bursitis and Achilles tendinopathy induced by two injections of recombinant human TGF-beta1 into the retrocalcaneal bursa
rHuPH20 rapidly cleared accumulated hyaluronan and CS/DS, restored geometric and material tendon properties to uninjured levels by 9 days, and produced targeted acute increases in cell fate, extracellular matrix metabolism and inflammatory gene expression. Effects were most evident at the acute and…
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