Noble gas neuroprotection: xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Gas applied to the slice culture chamber0.5 atm partial pressure of xenon, krypton, argon or neon;…Treatment started 10 min after oxygen-glucose deprivation
Model: Oxygen-glucose deprivation in organotypic hippocampal brain slices in vitro
Xenon and argon at 0.5 atm each reduced injury by 96 per cent and were not significantly different from uninjured sham slices, whereas helium, neon and krypton had no protective effect. Elevated glycine reversed the protection by xenon but not argon.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.