Comparison of the TLR4/NFkappaB and NLRP3 signalling pathways in major organs of the mouse after intravenous injection of lipopolysaccharide.
MouseEndotoxin/LPSICRMalen = 9 control, 15 lipopolysaccharide, 14 lipopolysaccharide plu…Intragastric0.5 mg/kg6 h after lipopolysaccharide injection
Model: Systemic multi-organ injury induced by intravenous lipopolysaccharide at 10 mg/kg
Lipopolysaccharide raised blood urea nitrogen, creatinine, ALT and AST by 81.42, 67.84, 40.53 and 36.05 per cent and lowered creatine kinase, ALP, total protein and albumin by 71.37, 60.6, 12.57 and 19.73 per cent, with widespread organ damage and upregulated TLR4/NF-kappaB signalling. Dexamethason…
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