Evaluation of the effects of erythropoietin and interleukin-6 in rats submitted to acute spinal cord injury.
RatSpinal cord injuryContusionWistarMalen = 50 rats randomised into 5 groups of 10; 4 animals died or w…IntraperitonealErythropoietin 1,000 IU/kg body weight; interleukin-6 200 I…First dose given immediately after the spinal cord contusion
Model: Acute spinal cord injury produced with a New York University weight-drop impactor at T10 after laminectomy, using a 10 g rod dropped from 12.5 mm
Erythropoietin alone gave significantly better BBB motor scores than the combination and other injured groups. The erythropoietin plus interleukin-6 combination was significantly worse than erythropoietin alone but better than interleukin-6 alone, and interleukin-6 alone was not superior to placebo…
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