THERAPY DOSSIER · th-1a0cb6936d89

Erythropoietin; interleukin-6

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01913340 ↗PHASE1/PHASE2completed

Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes (HIE)

Hypoxic-ischemic Encephalopathy

Enrolment: 50 · Results not recorded

NCT06590155 ↗EARLY_PHASE1not yet recruiting

Role of Erythropoietin in Neonates With HIE

Neonatal Hypoxic Ischemic Encephalopathy

Enrolment: 3 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31433044 ↗2019Mixed findings

Evaluation of the effects of erythropoietin and interleukin-6 in rats submitted to acute spinal cord injury.

RatSpinal cord injuryContusionWistarMalen = 50 rats randomised into 5 groups of 10; 4 animals died or w…IntraperitonealErythropoietin 1,000 IU/kg body weight; interleukin-6 200 I…First dose given immediately after the spinal cord contusion

Model: Acute spinal cord injury produced with a New York University weight-drop impactor at T10 after laminectomy, using a 10 g rod dropped from 12.5 mm

Erythropoietin alone gave significantly better BBB motor scores than the combination and other injured groups. The erythropoietin plus interleukin-6 combination was significantly worse than erythropoietin alone but better than interleukin-6 alone, and interleukin-6 alone was not superior to placebo…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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